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Chondrosarcoma, or cancer of chondroblasts that form cartilage, and fibrosarcoma, or cancer of cells that produce the bone collagen matrix, also are seen with some frequency. Primary bone tumors arise in the long bones of the limbs more commonly than the in “flat” bones of the body. But other types of tumors, like multilobular osteochondromas, are seen more often in the bones of the skull than in the long bones of the legs.

Metastatic tumors can start in many different organs. Cancers that are known to spread to bone start in the prostate gland and the mammary gland. Cancers that originate from cells that inhabit the bone marrow include lymphomas, leukemias, mast cell tumors, multiple myeloma, histiocytic sarcomas, and hemangiosarcomas.